From Wikipedia: Anglo-Powhatan Wars

The start of almost three centuries of continual warfare against native tribes.

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The Anglo–Powhatan Wars were three wars fought between settlers of the Virginia Colony and Algonquin Indians of the Powhatan Confederacy in the early seventeenth century. The first war started in 1609 and ended in a peace settlement in 1614. The second war lasted from 1622 to 1626. The third war lasted from 1644 until 1646 and ended when Opechancanough was captured and killed. That war resulted in a defined boundary between the Indians and colonial lands that could only be crossed for official business with a special pass. This situation lasted until 1677 and the Treaty of Middle Plantation which established Indian reservations following Bacon's Rebellion.

- First Anglo-Powhatan War (1609–1614)

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