From Ezra Klein's WonkBook:
The Senate will debate stripping the EPA's authority over climate change Thursday, reports Taylor Rushing: "The debate will center on a Thursday vote on a disapproval resolution by Sen. Lisa Murkowski (R-Alaska) that would block the EPA from enforcing emission rules under the Clean Air Act...Murkowski is bringing the resolution forward under the Congressional Review Act, which prevents any filibusters and only requires 51 votes for passage. Murkowski has said she has about 41 votes, including Democratic Sens. Mary Landrieu of Louisiana, Ben Nelson of Nebraska and Blanche Lincoln of Arkansas."
Wondering what the Congressional Review Act does? The Congressional Research Service has you covered. Bottom line: Senate can't filibuster, but the president can veto, and that means Murkowski's resolution would need 2/3rds of both the House and the Senate to make it into law.