For 2301 mostly:
Here's a terrific story about how members of the tea party movement are working from the ground up to takeover the Republican Party, which they see as too "establishment" and "liberal" and ensure that it only promotes candidates they find acceptable.
It begins with taking over precinct chairs an works its way up from there. The only potential strategic problem is that they may, as has been observed before, pull the party so far to the right that it becomes less competitive in general elections. But perhaps the general population is more conservative than thought. It'll be interesting to watch.
Commentators often equate the tea partiers with populist movements, fueled by anger at elites (any elite). American history is peppered with such movements. A key question is going to be how long the movement can survive. All movements have life cycles. The establishment can be very patient.